Endocrine Abstracts

A 52 year old gentleman was referred for an inpatient Endocrinology review. He was admitted after incidental finding of severe hyponatremia of 119. He felt unwell after having an episode of vomiting at home a few days ago and then had his bloods done at primary care. He denied any headache, dizziness, or visual disturbance. Further investigations were requested which revealed plasma osm 247, urine osm 350, and urine sodium 132. A diagnosis of SIADH was established and he was p...

Introduction: Hyperthyroidism is a pathological state characterized by increased synthesis and secretion of thyroid hormones (thyroxine (T4) and triiodothyronine (T3)) by the thyroid gland. Subclinical hyperthyroidism – a milder form – is defined as a low or suppressed TSH (<0.4 mIU/l), but serum free T4 (FT4) and free T3 (FT3) within the reference interval.Case: 76 years old lady seen in endocrine clinic. She was referred by GP because of ...

38 year old woman presented with palpitations, chest tightness, dizziness and light headedness. There was no evidence of infection clinically or biochemically. She had a background of Alemtuzumab induced Graves’ thyrotoxicosis, relapsing remitting Multiple Sclerosis. Her regular medications included Carbimazole 20 mg three times a day, Amitriptyline 120 mg daily, Propranolol 40 mg four times a day, Tizanidine 2 mg daily (up to 18 mg), Tramadol 50 mg as required, Senna 7.5...

Introduction: Dermoid cysts are rare (0.5% of intracranial tumours). They are best considered a spectrum: from epidermoid cysts containing desquamated squamous epithelium to teratomas containing all three embryonic tissues. Sellar dermoid cysts are even rarer [Orpha.net ID: ORPHA:91351]. Case: A 47-year old white British male was referred following incidental discovery of bitemporal field defect on routine eye test. He was otherwise completely asymptomat...

The pituicytomas are extremely rare and little-studied primary tumours of the adult neurohypophysis. These are low-grade (World Health Organization [WHO] grade 1), indolent gliomas which present as a sellar mass, which is usually mistaken for a pituitary adenoma, and has no known hormonal secretory function. A 63 years old retired paediatrician was referred to the neurology clinic with the history of constant severe headache ongoing for a few weeks. It involved the whole of th...

PCOS is the most common endocrine disorder affecting the women of reproductive age group and weight loss is the mainstay of management of PCOS. We performed an open-label randomised controlled trial to compare the effects of a conventional energy deficit approach (-600 kcal/day of the total energy requirements) vs. a very low-calorie diet (VLCD: 800 kcal/day) on free androgen index (FAI), body weight, and metabolic markers in women with PCOS. Forty-one eligible patients were r...

A 71-year-old woman was referred to the urology department with macroscopic haematuria. An ultrasound scan revealed a suspicious solid mass measuring 6.6cm arising from the left kidney. Subsequent CT scan confirmed the presence of a left adrenal mass along with omental and peritoneal disease and small-volume ascites. The patient was referred to the adrenal surgeons for consideration of left adrenalectomy in view of suspected adrenal cancer. At the surgical outpatient departmen...

Glucose is the primary source of energy for cells and its levels are tightly regulated by the hormone insulin. In people with diabetes, the body either doesn’t produce enough insulin or doesn’t respond to insulin properly. Hyperglycemia can occur which carries high morbidity and mortality. Some common signs and symptoms include polyuria, polydipsia, polyphagia and fatigue. Diabetic ketoacidosis and hyperosmolar hyperglycaemic state are serious medical emergencies ass...

MEN1 is a rare hereditary tumor syndrome characterized by a predisposition to a multitude of endocrine neoplasms primarily of parathyroid, enteropancreatic, and anterior pituitary origin and non endocrine tumor. Here we will discuss a case of 36 yrs. old male who was referred for high calcium on routine blood test. Subsequent investigations confirmed primary hyperparathyroidism. His serum calcium level was 2.71, PTH 7.5 Pmol/l, and vitamin D 57.4 nmol/l on presentation and was...

Introduction: Women with PCOS have a higher risk of metabolic syndrome and cardiovascular complications. We aimed to understand if routinely measured hormonal parameters can identify women with PCOS with a higher risk of metabolic syndrome (MetS).Methods: The data for the study consisted of a discovery cohort (PCOS clinic database) and a replication cohort (Hull PCOS Biobank.) We used eight routinely measured hormonal parameters in our clinics (free andr...